Jonathan Dinman to Direct the Institute for Bioscience and Biotechnology Research
Jonathan Dinman, a professor in the Department of Cell Biology and Molecular Genetics at the University of Maryland, College Park (UMCP), has been named director of the Institute for Bioscience and Biotechnology Research (IBBR), effective November 1, 2024. Located in the heart of Maryland’s biotechnology corridor in Montgomery County, IBBR...
Breakthrough Rapid Detection Method for Monoclonal Antibody Redox Modifications Published in Nature Chemical Biology
Monoclonal antibodies (mAbs) represent the largest class of the growing therapeutic protein market. The structure and function, and therefore the safety and efficacy, of these molecules can be affected by reduction-oxidation (redox)-based chemical modifications such as interchain disulfide bond reduction and methionine oxidation. In manufacturing, new analytical technologies are needed...
IBBR Researchers Participate in NIH Established Pandemic Preparedness Research Network
The University of Maryland Institute for Bioscience and Biotechnology Research (IBBR) received a $2.95M grant subaward from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH) to conduct cutting-edge research aimed at developing vaccines and monoclonal antibodies (mAbs) to combat high-priority viral...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Seminar: "Structure and function of transporters in synaptic vesicles"
Jonathan Coleman
University of Pittsburgh
Tuesday, January 21, 2025 - 11:00am
NIST Group Meeting; Sandeep Kumar
Wednesday, January 22, 2025 - 11:00am
Tuesday, January 28, 2025 - 11:00am
Recent Publications
AlphaFold and Docking Approaches for Antibody-Antigen and Other Targets: Insights From CAPRI Rounds 47-55.
Accurate modeling of the structures of protein-protein complexes and other biomolecular interactions represents a longstanding and important challenge for computational biology. The Critical...
Structure and dynamics of monoclonal antibody domains determined using spins, scattering, and simulations.
Antibody-based pharmaceuticals are the leading biologic drug platform (> $75B/year). Despite a wealth of information collected on them, there is still a lack of knowledge on their inter-domain...
Conformational dynamics and multi-modal interaction of Paxillin with the Focal Adhesion Targeting Domain.
Paxillin (PXN) and focal adhesion kinase (FAK) are two major components of the focal adhesion complex, a multiprotein structure linking the intracellular cytoskeleton to the cell exterior. PXN...
Recognition of Self and Viral Ligands by NK Cell Receptors.
Natural killer (NK) cells are essential elements of the innate immune response against tumors and viral infections. NK cell activation is governed by NK cell receptors that recognize both cellular...
Detection of Putative Ligand Dissociation Pathways in Proteins Using Site-Identification by Ligand Competitive Saturation.
Drug efficacy often correlates better with dissociation kinetics than binding affinity alone. To study binding kinetics computationally, it is necessary to identify all of the possible ligand...