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Edward Eisenstein Named Fellow of the American Society for Biochemistry and Molecular Biology (ASBMB)
Dr. Edward Eisenstein has been named a 2025 Fellow of the American Society for Biochemistry and Molecular Biology (ASBMB). This distinguished award recognizes his exceptional accomplishments and commitments to research, education, mentorship, diversity and inclusion, advocacy, and service to the broader scientific community.
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Structural Biology Day at IBBR
The Institute for Bioscience and Biotechnology Research (IBBR) invites you to participate in our second biennial Structural Biology Day on Wednesday, May 7, 2025 at our facility in Rockville, Maryland. The event will feature research talks in various aspects of structural biology, including cryoelectron microscopy, X-ray crystallography, mass spectrometry, diffraction...
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Megan Cleveland Awarded Presidential Early Career Award for Scientists and Engineers (PECASE)
Dr. Megan Cleveland, NIST-IBBR scientist, is among 400 early-career scientists to be honored with the Presidential Early Career Award for Scientists and Engineers (PECASE), the U.S. government's highest honor for outstanding early researchers. This recognition acknowledges her outstanding contributions to science and engineering. As part of the award, Dr. Cleveland...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Nikki Schneck
GSK
Monday, March 10, 2025 - 11:00am
NIST Group Meeting; Ashira Jayaweere
Wednesday, March 12, 2025 - 11:00am
BMD Staff Seminar A. Zuber/ S. Aalbers, .04/.06
Tuesday, March 25, 2025 - 11:00am
Recent Publications
Genomic characterization of the HER2-enriched intrinsic molecular subtype in primary ER-positive HER2-negative breast cancer.
ER-positive/HER2-negative (ERpHER2n) breast cancer classified as PAM50 HER2-enriched (ERpHER2n-HER2E) represents a small high-risk patient subgroup. In this study, we investigate genomic,...
Increasing the Accuracy and Robustness of the CHARMM General Force Field with an Expanded Training Set.
Small molecule empirical force fields (FFs), including the CHARMM General Force Field (CGenFF), are designed to have wide coverage of organic molecules and to rapidly assign parameters to...
Investigating the Interaction between Excipients and Monoclonal Antibodies PGT121 and N49P9.6-FR-LS: A Comprehensive Analysis.
N49P9.6-FR-LS and PGT121 are promising antibodies with significant therapeutic potential against HIV infection, but they are prone to precipitation at concentrations greater than 12 to 13 mg/mL....
Thermal proteome profiling and proteome analysis using high-definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next-generation galeterone analog VNPP433-3β in castration-resistant prostate cancer.
Cholesterol (CHOL) homeostasis is significantly modulated in prostate cancer (PCa) suggesting an active role in PCa development and progression. Several studies indicate a strong correlation...
RNA Helicase DDX3 Interacts with the Capsid Protein of Hepatitis E Virus and Plays a Vital Role in the Viral Replication.
DDX3 is an ATP-dependent RNA helicase that is involved in multiple cellular activities, including RNA metabolism and innate immunity. DDX3 is known to assist the replication of some viruses while...